‘Results of our study indicate that dietary exposure to aristolochic acid in this populace is causally related to endemic nephropathy and carcinomas of the higher urinary system in genetically susceptible individuals,’ says Dr. Grollman. ‘Implications of the outcomes go beyond the population of those exposed in the Balkans, as millions of people worldwide are in risk for developing diseases because of aristolochic acid exposure from traditional remedies ready from Aristolochia herbs.However the inherent value of the studies has arrive under scrutiny, in part because they generally ignore rare mutations. Given this flaw, experts have needed renewed focus on the uncommon mutations that might be more likely than frequently occurring ones to cause illness. The GWAS approach involves comparing the genomes of healthy people with those experiencing disease to pinpoint disease-associated solitary nucleotide polymorphisms typically within at least 5 percent of the population. .. Adding an antipsychotic to an antidepressant regimen might relieve treatment-resistant depression in seniors. A recent scientific trial examined aripiprazole augmentation in patients 60 ages and old with hard-to-treat depression.